Jennifer Grandis, MD

Associate Vice Chancellor, Clinical Research
Clinical and Translational Research
+1 415 514-8060

Jennifer R. Grandis, MD, is a Professor in the Department of Otolaryngology – Head and Neck Surgery (OHNS), and she is the Associate Vice Chancellor—Clinical and Translational Research (AVC-CTR) at the University of California, San Francisco. She received her medical degree from the University of Pittsburgh School of Medicine, Pennsylvania, and she completed her internship from the same institution. Dr. Grandis completed both a residency and an Infectious Disease fellowship from the University of Pittsburgh School of Medicine, Pennsylvania. Prior to joining UCSF, Dr. Grandis was the UPMC Endowed Chair in Head and Neck Cancer Surgical Research and Distinguished Professor of Otolaryngology and Pharmacology and Chemical Biology at the University of Pittsburgh. She led the Head and Neck Cancer Program and was the Vice Chair for Research in the Department of Otolaryngology.

Dr. Grandis’s research focuses on the signal transduction in head and neck squamous cell carcinoma (HNSCC) development and progression with the ultimate goal of targeting key pathways for therapeutic benefit. By taking key findings from the clinic and investigating mechanisms in a series of preclinical models, as well as developing novel therapeutic approaches in the laboratory and carrying out innovative clinical trials that employ these treatment strategies.

Dr. Grandis is an American Cancer Society Clinical Research Professor, and a member of the American Society for Clinical Investigation, the American Association of Physicians and the Institute of Medicine of the National Academies. She has published over 260 peer-reviewed articles. She has also contributed to more than 50 review articles and book chapters.

Research:
Dr. Grandis's is dedicated to increasing our understanding of the genetic and epigenetic alterations in the upper aerodigestive tract mucosa, which mediate head and neck squamous cell carcinoma (HNSCC) progression. The overall goal is to identify predictive biomarkers, which can serve to select patients for therapies, including molecular targeting approaches. Translational resources developed to support projects include a large collection of patient-derived xenografts (PDXs) and tissue microarrays of over 500 human HNSCCs linked to a professionally curated clinical and pathologic database that includes information on treatment and survival. To date, the have examined the role of the epidermal growth factor receptor (EGFR), it’s ligands coordinate activation of STAT3 (signal transducer and activator of transcription) in head and neck carcinogenesis. Cumulative evidence from her laboratory suggests that TGF-?lpha/EGFR autocrine signaling leading to STAT3 activation is as early event in head and neck carcinogenesis. Strategies aimed at blocking the ligand, receptor or signaling protein demonstrated anti-tumor efficacy in preclinical models. Based on these promising results, they completed a Phase I clinical trial to investigate the toxicity and biologic effects of EGFR antisense gene therapy and a Phase II study was recently closed to accrual. They have developed STAT3 targeting strategies using a decoy oligonucleotide approach and early phase clinical testing demonstrated feasibility without toxicity. Ongoing studies are aimed at identifying the targetable genetic alterations in these cancers with the goal of designing precision medicine approaches. Emerging targets include activating mutations of the PI3K signaling pathway, primarily in HNSCC linked to HPV infection and mutation or promoter hypermethylation of selected PTPRs, which lead to STAT3 activation.

Specialty:
General Otolaryngology

Expertise:
Clinical and translational research

Professional Interests:
Head and neck cancer, signal transduction, precision medicine, experimental therapeutics, preclinical cancer models, receptor crosstalk

Education and Training:
• Medical School: University of Pittsburgh School of Medicine, Pittsburgh, PA
• Internship: University of Pittsburgh School of Medicine, Pittsburgh, PA
• Residency: University of Pittsburgh School of Medicine, Pittsburgh, PA
• Fellowship: University of Pittsburgh School of Medicine, Pittsburgh, PA – Infectious Disease

Publications: 

EGFR-targeted therapies in the post-genomic era.

Cancer metastasis reviews

Xu MJ, Johnson DE, Grandis JR

The fourth edition of the head and neck World Health Organization blue book: editors' perspectives.

Human pathology

El-Naggar AK, Chan JKC, Takata T, Grandis JR, Slootweg PJ

Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.

Science translational medicine

Sun C, Fang Y, Yin J, Chen J, Ju Z, Zhang D, Chen X, Vellano CP, Jeong KJ, Ng PK, Eterovic AKB, Bhola NH, Lu Y, Westin SN, Grandis JR, Lin SY, Scott KL, Peng G, Brugge J, Mills GB

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines.

Journal of chemical biology

Sen M, Johnston PA, Pollock NI, DeGrave K, Joyce SC, Freilino ML, Hua Y, Camarco DP, Close DA, Huryn DM, Wipf P, Grandis JR

IL6 is associated with response to dasatinib and cetuximab: Phase II clinical trial with mechanistic correlatives in cetuximab-resistant head and neck cancer.

Oral oncology

Stabile LP, Egloff AM, Gibson MK, Gooding WE, Ohr J, Zhou P, Rothenberger NJ, Wang L, Geiger JL, Flaherty JT, Grandis JR, Bauman JE

TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.

Genes, chromosomes & cancer

Kulkarni S, Bill A, Godse NR, Khan NI, Kass JI, Steehler K, Kemp C, Davis K, Bertrand CA, Vyas AR, Holt DE, Grandis JR, Gaither LA, Duvvuri U

Nonpromoter methylation of the CDKN2A gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma.

Cancer medicine

Ben-Dayan MM, Ow TJ, Belbin TJ, Wetzler J, Smith RV, Childs G, Diergaarde B, Hayes DN, Grandis JR, Prystowsky MB, Schlecht NF

Exome and genome sequencing of nasopharynx cancer identifies NF-?B pathway activating mutations.

Nature communications

Li YY, Chung GT, Lui VW, To KF, Ma BB, Chow C, Woo JK, Yip KY, Seo J, Hui EP, Mak MK, Rusan M, Chau NG, Or YY, Law MH, Law PP, Liu ZW, Ngan HL, Hau PM, Verhoeft KR, Poon PH, Yoo SK, Shin JY, Lee SD, Lun SW, Jia L, Chan AW, Chan JY, Lai PB, Fung CY, Hung ST, Wang L, Chang AM, Chiosea SI, Hedberg ML, Tsao SW, van Hasselt AC, Chan AT, Grandis JR, Hammerman PS, Lo KW

Cancer genomics: Spot the difference.

Nature

Peyser ND, Grandis JR

Human papillomavirus regulates HER3 expression in head and neck cancer: implications for targeted HER3 therapy in HPV(+) patients.

Clinical cancer research : an official journal of the American Association for Cancer Research

Brand TM, Hartmann S, Bhola NE, Peyser ND, Li H, Zeng Y, Isaacson Wechsler E, Ranall MV, Bandyopadhyay S, Duvvuri U, LaVallee TM, Jordan RC, Johnson DE, Grandis JR

Head and neck cancer in 2016: A watershed year for improvements in treatment?

Nature reviews. Clinical oncology

Algazi AP, Grandis JR

Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer.

PloS one

Peyser ND, Pendleton K, Gooding WE, Lui VW, Johnson DE, Grandis JR

Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation.

Cancer chemotherapy and pharmacology

Kiesel BF, Parise RA, Guo J, Huryn DM, Johnston PA, Colombo R, Sen M, Grandis JR, Beumer JH, Eiseman JL

Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

Nature genetics

Lesseur C, Diergaarde B, Olshan AF, Wünsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Neto J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesel J, Kjaerheim K, Zaridze D, Johansson M, Menezes AM, Curado MP, Robinson M, Ahrens W, Canova C, Znaor A, Castellsagué X, Conway DI, Holcátová I, Mates D, Vilensky M, Healy CM, Szeszenia-Dabrowska N, Fabiánová E, Lissowska J, Grandis JR, Weissler MC, Tajara EH, Nunes FD, de Carvalho MB, Thomas S, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P

A sensible approach to targeting STAT3-mediated transcription.

Annals of translational medicine

Bhola NE, Johnson DE, Grandis JR

Treatment of head and neck cancer in the elderly.

Expert opinion on pharmacotherapy

Hartmann S, Grandis JR

The non-coding landscape of head and neck squamous cell carcinoma.

Oncotarget

Zou AE, Zheng H, Saad MA, Rahimy M, Ku J, Kuo SZ, Honda TK, Wang-Rodriguez J, Xuan Y, Korrapati A, Yu V, Singh P, Grandis JR, King CC, Lippman SM, Wang XQ, Hinton A, Ongkeko WM

HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment.

Clinical cancer research : an official journal of the American Association for Cancer Research

Hartmann S, Bhola NE, Grandis JR

New Strategies in Esophageal Carcinoma: Translational Insights from Signaling Pathways and Immune Checkpoints.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wang VE, Grandis JR, Ko AH

Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane.

Cancer prevention research (Philadelphia, Pa.)

Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.

Bioorganic & medicinal chemistry letters

LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, Huryn DM

STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma.

Cancer prevention research (Philadelphia, Pa.)

Peyser ND, Wang L, Zeng Y, Acquafondata M, Freilino M, Li H, Sen M, Gooding WE, Satake M, Wang Z, Johnson DE, Grandis JR

Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma.

Head & neck

Geiger JL, Bauman JE, Gibson MK, Gooding WE, Varadarajan P, Kotsakis A, Martin D, Gutkind JS, Hedberg ML, Grandis JR, Argiris A

Phase II randomized trial of radiation therapy, cetuximab, and pemetrexed with or without bevacizumab in patients with locally advanced head and neck cancer.

Annals of oncology : official journal of the European Society for Medical Oncology / ESMO

Argiris A, Bauman JE, Ohr J, Gooding WE, Heron DE, Duvvuri U, Kubicek GJ, Posluszny DM, Vassilakopoulou M, Kim S, Grandis JR, Johnson JT, Gibson MK, Clump DA, Flaherty JT, Chiosea SI, Branstetter B, Ferris RL

The degree of intratumor mutational heterogeneity varies by primary tumor sub-site.

Oncotarget

Ledgerwood LG, Kumar D, Eterovic AK, Wick J, Chen K, Zhao H, Tazi L, Manna P, Kerley S, Joshi R, Wang L, Chiosea SI, Garnett JD, Tsue TT, Chien J, Mills GB, Grandis JR, Thomas SM

Corrigendum to "Cetuximab activity in dysplastic lesions of the upper aerodigestive tract" [Oral Oncol. 53 (2016) 60-66].

Oral oncology

Khan Z, Epstein JB, Marur S, Boyd Gillespie M, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris RL, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung CH, Califano JA

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.

The Journal of clinical investigation

Hedberg ML, Goh G, Chiosea SI, Bauman JE, Freilino ML, Zeng Y, Wang L, Diergaarde BB, Gooding WE, Lui VW, Herbst RS, Lifton RP, Grandis JR

HER2 and HER3 in HPV+ and HPV- HNSCC-Response.

Clinical cancer research : an official journal of the American Association for Cancer Research

Grandis J

A Young Man With Chronic Discharge From the Skin of the Lateral Neck.

JAMA otolaryngology-- head & neck surgery

Prabhu AV, Grandis J, Branstetter BF

Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts.

Molecular cancer research : MCR

Li H, Wheeler S, Park Y, Ju Z, Thomas SM, Fichera M, Egloff AM, Lui VW, Duvvuri U, Bauman JE, Mills GB, Grandis JR

Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population.

Cancer research

Bhola NE, Jansen VM, Koch JP, Li H, Formisano L, Williams JA, Grandis JR, Arteaga CL

Cetuximab activity in dysplastic lesions of the upper aerodigestive tract.

Oral oncology

Khan Z, Epstein JB, Marur S, Gillespie MB, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris R, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung C, Califano JA

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.

The Journal of clinical investigation

Hedberg ML, Goh G, Chiosea SI, Bauman JE, Freilino ML, Zeng Y, Wang L, Diergaarde BB, Gooding WE, Lui VW, Herbst RS, Lifton RP, Grandis JR

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.

The Journal of clinical investigation

Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC

MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer.

BMC cancer

Chapman BV, Wald AI, Akhtar P, Munko AC, Xu J, Gibson SP, Grandis JR, Ferris RL, Khan SA

Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth.

Theranostics

Kopechek JA, Carson AR, McTiernan CF, Chen X, Hasjim B, Lavery L, Sen M, Grandis JR, Villanueva FS

HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines.

Assay and drug development technologies

Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Wilson GM, Resnick LO, LaPorte MG, Wipf P, Huryn DM, Grandis JR

Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies.

Clinical cancer research : an official journal of the American Association for Cancer Research

Pollock NI, Wang L, Wallweber G, Gooding WE, Huang W, Chenna A, Winslow J, Sen M, DeGrave KA, Li H, Zeng Y, Grandis JR

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.

JAMA oncology

Van Allen EM, Lui VW, Egloff AM, Goetz EM, Li H, Johnson JT, Duvvuri U, Bauman JE, Stransky N, Zeng Y, Gilbert BR, Pendleton KP, Wang L, Chiosea S, Sougnez C, Wagle N, Zhang F, Du Y, Close D, Johnston PA, McKenna A, Carter SL, Golub TR, Getz G, Mills GB, Garraway LA, Grandis JR

Emerging drugs for head and neck cancer.

Expert opinion on emerging drugs

Wen Y, Grandis JR

JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth.

Neoplasia (New York, N.Y.)

Sen M, Pollock NI, Black J, DeGrave KA, Wheeler S, Freilino ML, Joyce S, Lui VW, Zeng Y, Chiosea SI, Grandis JR

Challenges in EGFRvIII detection in head and neck squamous cell carcinoma.

PloS one

Wheeler SE, Egloff AM, Wang L, James CD, Hammerman PS, Grandis JR

Incidence of head and neck squamous cell carcinoma among subjects at high risk of lung cancer: results from the Pittsburgh Lung Screening Study.

Cancer

Dixit R, Weissfeld JL, Wilson DO, Balogh P, Sufka P, Siegfried JM, Grandis JR, Diergaarde B

Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma.

Cancer letters

Fung C, Zhou P, Joyce S, Trent K, Yuan JM, Grandis JR, Weissfeld JL, Romkes M, Weeks DE, Egloff AM

HER2 as a therapeutic target in head and neck squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Pollock NI, Grandis JR

Receptor-type protein tyrosine phosphatases in cancer.

Chinese journal of cancer

Du Y, Grandis JR

Characterization of HPV and host genome interactions in primary head and neck cancers.

Proceedings of the National Academy of Sciences of the United States of America

Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.

Bioorganic & medicinal chemistry letters

LaPorte MG, da Paz Lima DJ, Zhang F, Sen M, Grandis JR, Camarco D, Hua Y, Johnston PA, Lazo JS, Resnick LO, Wipf P, Huryn DM

Quantifying metabolic heterogeneity in head and neck tumors in real time: 2-DG uptake is highest in hypoxic tumor regions.

PloS one

Nakajima EC, Laymon C, Oborski M, Hou W, Wang L, Grandis JR, Ferris RL, Mountz JM, Van Houten B

Phase II study of cetuximab in combination with cisplatin and radiation in unresectable, locally advanced head and neck squamous cell carcinoma: Eastern cooperative oncology group trial E3303.

Clinical cancer research : an official journal of the American Association for Cancer Research

Egloff AM, Lee JW, Langer CJ, Quon H, Vaezi A, Grandis JR, Seethala RR, Wang L, Shin DM, Argiris A, Yang D, Mehra R, Ridge JA, Patel UA, Burtness BA, Forastiere AA

Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss.

Nature genetics

Gross AM, Orosco RK, Shen JP, Egloff AM, Carter H, Hofree M, Choueiri M, Coffey CS, Lippman SM, Hayes DN, Cohen EE, Grandis JR, Nguyen QT, Ideker T

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.

The Journal of clinical investigation

Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu B, Yan H, Cheng SY

Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.

PloS one

Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL

To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN.

Clinical cancer research : an official journal of the American Association for Cancer Research

Shiwarski DJ, Shao C, Bill A, Kim J, Xiao D, Bertrand CA, Seethala RS, Sano D, Myers JN, Ha P, Grandis J, Gaither LA, Puthenveedu MA, Duvvuri U

Targeting secondary immune responses to cetuximab: CD137 and the outside story.

The Journal of clinical investigation

Bauman JE, Grandis JR

Epidemiology of head and neck squamous cell cancer among HIV-infected patients.

Journal of acquired immune deficiency syndromes (1999)

D'souza G, Carey TE, William WN, Nguyen ML, Ko EC, Riddell J, Pai SI, Gupta V, Walline HM, Lee JJ, Wolf GT, Shin DM, Grandis JR, Ferris RL

Erlotinib, erlotinib-sulindac versus placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Gross ND, Bauman JE, Gooding WE, Denq W, Thomas SM, Wang L, Chiosea S, Hood BL, Flint MS, Sun M, Conrads TP, Ferris RL, Johnson JT, Kim S, Argiris A, Wirth L, Nikiforova MN, Siegfried JM, Grandis JR

Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing toxicological effects.

Molecular medicine (Cambridge, Mass.)

Sen M, Paul K, Freilino ML, Li H, Li C, Johnson DE, Wang L, Eiseman J, Grandis JR

Genomic analysis of head and neck squamous cell carcinoma cell lines and human tumors: a rational approach to preclinical model selection.

Molecular cancer research : MCR

Li H, Wawrose JS, Gooding WE, Garraway LA, Lui VW, Peyser ND, Grandis JR

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.

Proceedings of the National Academy of Sciences of the United States of America

Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ, Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, Du Y, Vries JK, Hammerman PS, Garraway LA, Mills GB, Johnson DE, Grandis JR

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma.

BMC cancer

Chiosea SI, Grandis JR, Lui VW, Diergaarde B, Maxwell JH, Ferris RL, Kim SW, Luvison A, Miller M, Nikiforova MN

Integration of molecular targeted therapy with radiation in head and neck cancer.

Pharmacology & therapeutics

Du Y, Peyser ND, Grandis JR

Collagen type XI a1 facilitates head and neck squamous cell cancer growth and invasion.

British journal of cancer

Sok JC, Lee JA, Dasari S, Joyce S, Contrucci SC, Egloff AM, Trevelline BK, Joshi R, Kumari N, Grandis JR, Thomas SM

High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines.

Assay and drug development technologies

Johnston PA, Sen M, Hua Y, Camarco D, Shun TY, Lazo JS, Grandis JR

Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study.

Cancer prevention research (Philadelphia, Pa.)

Saba NF, Hurwitz SJ, Kono SA, Yang CS, Zhao Y, Chen Z, Sica G, Müller S, Moreno-Williams R, Lewis M, Grist W, Chen AY, Moore CE, Owonikoko TK, Ramalingam S, Beitler JJ, Nannapaneni S, Shin HJ, Grandis JR, Khuri FR, Chen ZG, Shin DM

Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer.

Oncogene

Panupinthu N, Yu S, Zhang D, Zhang F, Gagea M, Lu Y, Grandis JR, Dunn SE, Lee HY, Mills GB

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

Cancer discovery

Lui VW, Hedberg ML, Li H, Vangara BS, Pendleton K, Zeng Y, Lu Y, Zhang Q, Du Y, Gilbert BR, Freilino M, Sauerwein S, Peyser ND, Xiao D, Diergaarde B, Wang L, Chiosea S, Seethala R, Johnson JT, Kim S, Duvvuri U, Ferris RL, Romkes M, Nukui T, Kwok-Shing Ng P, Garraway LA, Hammerman PS, Mills GB, Grandis JR

Childhood passive smoke exposure is associated with adult head and neck cancer.

Cancer epidemiology

Troy JD, Grandis JR, Youk AO, Diergaarde B, Romkes M, Weissfeld JL

Polymorphisms in NAT2 and GSTP1 are associated with survival in oral and oropharyngeal cancer.

Cancer epidemiology

Troy JD, Weissfeld JL, Diergaarde B, Youk AO, Buch SC, Romkes M, Grandis JR

Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies.

Clinical cancer research : an official journal of the American Association for Cancer Research

Shin DM, Zhang H, Saba NF, Chen AY, Nannapaneni S, Amin AR, Müller S, Lewis M, Sica G, Kono S, Brandes JC, Grist WJ, Moreno-Williams R, Beitler JJ, Thomas SM, Chen Z, Shin HJ, Grandis JR, Khuri FR, Chen ZG

The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma.

Mutation research

Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI

Utility of 3'-[(18)F]fluoro-3'-deoxythymidine as a PET tracer to monitor response to gene therapy in a xenograft model of head and neck carcinoma.

American journal of nuclear medicine and molecular imaging

Mason NS, Lopresti BJ, Ruszkiewicz J, Dong X, Joyce S, Leef G, Sen M, Wahed AS, Mathis CA, Grandis JR, Thomas SM

c-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-Met.

Clinical cancer research : an official journal of the American Association for Cancer Research

Stabile LP, He G, Lui VW, Thomas S, Henry C, Gubish CT, Joyce S, Quesnelle KM, Siegfried JM, Grandis JR

Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.

ACS chemical biology

Thomas SM, Sahu B, Rapireddy S, Bahal R, Wheeler SE, Procopio EM, Kim J, Joyce SC, Contrucci S, Wang Y, Chiosea SI, Lathrop KL, Watkins S, Grandis JR, Armitage BA, Ly DH

Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models.

Neoplasia (New York, N.Y.)

Cassell A, Freilino ML, Lee J, Barr S, Wang L, Panahandeh MC, Thomas SM, Grandis JR

EGFR tyrosine kinase inhibition induces autophagy in cancer cells.

Cancer biology & therapy

Fung C, Chen X, Grandis JR, Duvvuri U

Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Zang Y, Thomas SM, Chan ET, Kirk CJ, Freilino ML, DeLancey HM, Grandis JR, Li C, Johnson DE

Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck.

Annals of oncology : official journal of the European Society for Medical Oncology / ESMO

Argiris A, Kotsakis AP, Hoang T, Worden FP, Savvides P, Gibson MK, Gyanchandani R, Blumenschein GR, Chen HX, Grandis JR, Harari PM, Kies MS, Kim S

Preclinical modeling of EGFR inhibitor resistance in head and neck cancer.

Cancer biology & therapy

Quesnelle KM, Wheeler SE, Ratay MK, Grandis JR

Targeting Stat3 abrogates EGFR inhibitor resistance in cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Sen M, Joyce S, Panahandeh M, Li C, Thomas SM, Maxwell J, Wang L, Gooding WE, Johnson DE, Grandis JR

Molecular pathways: context-dependent approaches to Notch targeting as cancer therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Egloff AM, Grandis JR

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.

Cancer discovery

Sen M, Thomas SM, Kim S, Yeh JI, Ferris RL, Johnson JT, Duvvuri U, Lee J, Sahu N, Joyce S, Freilino ML, Shi H, Li C, Ly D, Rapireddy S, Etter JP, Li PK, Wang L, Chiosea S, Seethala RR, Gooding WE, Chen X, Kaminski N, Pandit K, Johnson DE, Grandis JR

TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.

Cancer research

Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock JR, Harfe BD, Henson BJ, Kunzelmann K, Schreiber R, Seethala RS, Egloff AM, Chen X, Lui VW, Grandis JR, Gollin SM

Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wheeler SE, Morariu EM, Bednash JS, Otte CG, Seethala RR, Chiosea SI, Grandis JR

Antitumor mechanisms of targeting the PDK1 pathway in head and neck cancer.

Molecular cancer therapeutics

Bhola NE, Freilino ML, Joyce SC, Sen M, Thomas SM, Sahu A, Cassell A, Chen CS, Grandis JR

Elevated gastrin-releasing peptide receptor mRNA expression in buccal mucosa: association with head and neck squamous cell carcinoma.

Head & neck

Egloff AM, Liu X, Davis AL, Trevelline BK, Vuga M, Siegfried JM, Grandis JR

Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wheeler S, Siwak DR, Chai R, LaValle C, Seethala RR, Wang L, Cieply K, Sherer C, Joy C, Mills GB, Argiris A, Siegfried JM, Grandis JR, Egloff AM

Antitumor effect of vandetanib through EGFR inhibition in head and neck squamous cell carcinoma.

Head & neck

Klein JD, Christopoulos A, Ahn SM, Gooding WE, Grandis JR, Kim S

Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study.

Respiratory research

Egloff AM, Gaither Davis A, Shuai Y, Land S, Pilewski JM, Luketich JD, Landreneau R, Miller YE, Grandis JR, Siegfried JM

Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) polymorphism on outcome of advanced-stage squamous cell carcinoma of the head and neck are treatment dependent.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Zhong S, Nukui T, Buch S, Diergaarde B, Weissfeld LA, Grandis J, Romkes M, Weissfeld JL

Serum biomarkers as potential predictors of antitumor activity of cetuximab-containing therapy for locally advanced head and neck cancer.

Oral oncology

Argiris A, Lee SC, Feinstein T, Thomas S, Branstetter BF, Seethala R, Wang L, Gooding W, Grandis JR, Ferris RL

Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies.

Investigational new drugs

Argiris A, Feinstein TM, Wang L, Yang T, Agrawal S, Appleman LJ, Stoller RG, Grandis JR, Egloff AM

Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

Clinical cancer research : an official journal of the American Association for Cancer Research

Zhao M, Sano D, Pickering CR, Jasser SA, Henderson YC, Clayman GL, Sturgis EM, Ow TJ, Lotan R, Carey TE, Sacks PG, Grandis JR, Sidransky D, Heldin NE, Myers JN

Targeting mesenchymal exaptation to mitigate tumor growth.

Cell cycle (Georgetown, Tex.)

Thomas SM, Grandis JR

The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy.

American journal of clinical oncology

Rwigema JC, Heron DE, Ferris RL, Andrade RS, Gibson MK, Yang Y, Ozhasoglu C, Argiris AE, Grandis JR, Burton SA

The mutational landscape of head and neck squamous cell carcinoma.

Science (New York, N.Y.)

Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC, Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K, Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR

Dual kinase inhibition of EGFR and HER2 overcomes resistance to cetuximab in a novel in vivo model of acquired cetuximab resistance.

Clinical cancer research : an official journal of the American Association for Cancer Research

Quesnelle KM, Grandis JR

Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities: Report of an NCI Workshop held September 1-3, 2010.

Radiation research

Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S, Bernhard EJ

Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010.

Radiation research

Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S, Bernhard EJ

XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research

Vaezi A, Wang X, Buch S, Gooding W, Wang L, Seethala RR, Weaver DT, D'Andrea AD, Argiris A, Romkes M, Niedernhofer LJ, Grandis JR

Targeting GPCR-mediated p70S6K activity may improve head and neck cancer response to cetuximab.

Clinical cancer research : an official journal of the American Association for Cancer Research

Bhola NE, Thomas SM, Freilino M, Joyce S, Sahu A, Maxwell J, Argiris A, Seethala R, Grandis JR

Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells.

Clinical cancer research : an official journal of the American Association for Cancer Research

Xu H, Stabile LP, Gubish CT, Gooding WE, Grandis JR, Siegfried JM

Phase I trial of pemetrexed in combination with cetuximab and concurrent radiotherapy in patients with head and neck cancer.

Annals of oncology : official journal of the European Society for Medical Oncology / ESMO

Argiris A, Karamouzis MV, Smith R, Kotsakis A, Gibson MK, Lai SY, Kim S, Branstetter BF, Shuai Y, Romkes M, Wang L, Grandis JR, Ferris RL, Johnson JT, Heron DE

Sequential activation of inflammatory signaling pathways during graft-versus-host disease (GVHD): early role for STAT1 and STAT3.

Cellular immunology

Ma HH, Ziegler J, Li C, Sepulveda A, Bedeir A, Grandis J, Lentzsch S, Mapara MY

STAT3 signaling: anticancer strategies and challenges.

Molecular interventions

Johnston PA, Grandis JR

Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy.

Head & neck

Feinstein TM, Lai SY, Lenzner D, Gooding W, Ferris RL, Grandis JR, Myers EN, Johnson JT, Heron DE, Argiris A

Response to combined molecular targeting: defining the role of P-STAT3.

Clinical cancer research : an official journal of the American Association for Cancer Research

Egloff AM, Grandis JR

Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma.

Cancer prevention research (Philadelphia, Pa.)

Leeman-Neill RJ, Seethala RR, Singh SV, Freilino ML, Bednash JS, Thomas SM, Panahandeh MC, Gooding WE, Joyce SC, Lingen MW, Neill DB, Grandis JR

Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Argiris A, Heron DE, Smith RP, Kim S, Gibson MK, Lai SY, Branstetter BF, Posluszny DM, Wang L, Seethala RR, Dacic S, Gooding W, Grandis JR, Johnson JT, Ferris RL

Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome.

Clinical cancer research : an official journal of the American Association for Cancer Research

Stabile LP, Dacic S, Land SR, Lenzner DE, Dhir R, Acquafondata M, Landreneau RJ, Grandis JR, Siegfried JM

MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck.

Cancer

Langevin SM, Stone RA, Bunker CH, Lyons-Weiler MA, LaFramboise WA, Kelly L, Seethala RR, Grandis JR, Sobol RW, Taioli E

Determinants of head and neck cancer survival by race.

Head & neck

Ragin CC, Langevin SM, Marzouk M, Grandis J, Taioli E

Human papillomavirus and head and neck cancer.

Oncology (Williston Park, N.Y.)

Diergaarde B, Grandis JR

Emerging drugs to treat squamous cell carcinomas of the head and neck.

Expert opinion on emerging drugs

Fung C, Grandis JR

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation.

Oncogene

Wheeler SE, Suzuki S, Thomas SM, Sen M, Leeman-Neill RJ, Chiosea SI, Kuan CT, Bigner DD, Gooding WE, Lai SY, Grandis JR

Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR.

Clinical cancer research : an official journal of the American Association for Cancer Research

Ostrow KL, Hoque MO, Loyo M, Brait M, Greenberg A, Siegfried JM, Grandis JR, Gaither Davis A, Bigbee WL, Rom W, Sidransky D

Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer.

Cancer prevention research (Philadelphia, Pa.)

Taoudi Benchekroun M, Saintigny P, Thomas SM, El-Naggar AK, Papadimitrakopoulou V, Ren H, Lang W, Fan YH, Huang J, Feng L, Lee JJ, Kim ES, Hong WK, Johnson FM, Grandis JR, Mao L

Quantitative proteomics analysis reveals molecular networks regulated by epidermal growth factor receptor level in head and neck cancer.

Journal of proteome research

Yang W, Cai Q, Lui VW, Everley PA, Kim J, Bhola N, Quesnelle KM, Zetter BR, Steen H, Freeman MR, Grandis JR

Investigational EGFR-targeted therapy in head and neck squamous cell carcinoma.

Expert opinion on investigational drugs

Cassell A, Grandis JR

Response assessment by combined PET-CT scan versus CT scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy.

Annals of oncology : official journal of the European Society for Medical Oncology / ESMO

Passero VA, Branstetter BF, Shuai Y, Heron DE, Gibson MK, Lai SY, Kim SW, Grandis JR, Ferris RL, Johnson JT, Argiris A

New strategies in head and neck cancer: understanding resistance to epidermal growth factor receptor inhibitors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Chen LF, Cohen EE, Grandis JR

Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Leeman-Neill RJ, Cai Q, Joyce SC, Thomas SM, Bhola NE, Neill DB, Arbiser JL, Grandis JR

Nuclear localization of signal transducer and activator of transcription 3 in head and neck squamous cell carcinoma is associated with a better prognosis.

Clinical cancer research : an official journal of the American Association for Cancer Research

Pectasides E, Egloff AM, Sasaki C, Kountourakis P, Burtness B, Fountzilas G, Dafni U, Zaramboukas T, Rampias T, Rimm D, Grandis J, Psyrri A

The impact of health insurance status on the survival of patients with head and neck cancer.

Cancer

Kwok J, Langevin SM, Argiris A, Grandis JR, Gooding WE, Taioli E

The molecular pathogenesis of head and neck cancer.

Cancer biology & therapy

Klein JD, Grandis JR

Molecular changes in the multistage pathogenesis of head and neck cancer.

Cancer biomarkers : section A of Disease markers

Park BJ, Chiosea SI, Grandis JR

Management of patients treated with chemoradiotherapy for head and neck cancer without prophylactic feeding tubes: the University of Pittsburgh experience.

The Laryngoscope

McLaughlin BT, Gokhale AS, Shuai Y, Diacopoulos J, Carrau R, Heron DE, Smith RP, Gibson MK, Ferris RL, Grandis JR, Johnson JT, Argiris A

The current state of head and neck cancer gene therapy.

Human gene therapy

Thomas SM, Grandis JR

Systematic prediction of human membrane receptor interactions.

Proteomics

Qi Y, Dhiman HK, Bhola N, Budyak I, Kar S, Man D, Dutta A, Tirupula K, Carr BI, Grandis J, Bar-Joseph Z, Klein-Seetharaman J

An informatics supported web-based data annotation and query tool to expedite translational research for head and neck malignancies.

BMC cancer

Amin W, Kang HP, Egloff AM, Singh H, Trent K, Ridge-Hetrick J, Seethala RR, Grandis J, Parwani AV

STAT3 activation contributes directly to Epstein-Barr virus-mediated invasiveness of nasopharyngeal cancer cells in vitro.

International journal of cancer. Journal international du cancer

Lui VW, Wong EY, Ho Y, Hong B, Wong SC, Tao Q, Choi GC, Au TC, Ho K, Yau DM, Ma BB, Hui EP, Chan AS, Tsang CM, Tsao SW, Grandis JR, Chan AT

Cross-talk between estrogen receptor and epidermal growth factor receptor in head and neck squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Egloff AM, Rothstein ME, Seethala R, Siegfried JM, Grandis JR, Stabile LP

Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3.

Carcinogenesis

Leeman-Neill RJ, Wheeler SE, Singh SV, Thomas SM, Seethala RR, Neill DB, Panahandeh MC, Hahm ER, Joyce SC, Sen M, Cai Q, Freilino ML, Li C, Johnson DE, Grandis JR

HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Knowles LM, Stabile LP, Egloff AM, Rothstein ME, Thomas SM, Gubish CT, Lerner EC, Seethala RR, Suzuki S, Quesnelle KM, Morgan S, Ferris RL, Grandis JR, Siegfried JM

Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial.

International journal of radiation oncology, biology, physics

Heron DE, Ferris RL, Karamouzis M, Andrade RS, Deeb EL, Burton S, Gooding WE, Branstetter BF, Mountz JM, Johnson JT, Argiris A, Grandis JR, Lai SY

PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells.

Oncogene

Sun Q, Ming L, Thomas SM, Wang Y, Chen ZG, Ferris RL, Grandis JR, Zhang L, Yu J

Targeting angiogenesis from premalignancy to metastases.

Cancer prevention research (Philadelphia, Pa.)

Grandis JR, Argiris A

Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells.

Cancer immunology, immunotherapy : CII

López-Albaitero A, Lee SC, Morgan S, Grandis JR, Gooding WE, Ferrone S, Ferris RL

Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Lai SY, Koppikar P, Thomas SM, Childs EE, Egloff AM, Seethala RR, Branstetter BF, Gooding WE, Muthukrishnan A, Mountz JM, Lui VW, Shin DM, Agarwala SS, Johnson R, Couture LA, Myers EN, Johnson JT, Mills G, Argiris A, Grandis JR

Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond.

Seminars in radiation oncology

Harari PM, Wheeler DL, Grandis JR

Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting.

Clinical cancer research : an official journal of the American Association for Cancer Research

Koppikar P, Lui VW, Man D, Xi S, Chai RL, Nelson E, Tobey AB, Grandis JR

Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas.

Molecular cancer research : MCR

Zhang W, Bhola N, Kalyankrishna S, Gooding W, Hunt J, Seethala R, Grandis JR, Siegfried JM

Genetic screening for oral human papillomavirus infections and cancers of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research

Sok JC, Grandis JR

Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zou H, Thomas SM, Yan ZW, Grandis JR, Vogt A, Li LY

Lack of toxicity of a STAT3 decoy oligonucleotide.

Cancer chemotherapy and pharmacology

Sen M, Tosca PJ, Zwayer C, Ryan MJ, Johnson JD, Knostman KA, Giclas PC, Peggins JO, Tomaszewski JE, McMurray TP, Li C, Leibowitz MS, Ferris RL, Gooding WE, Thomas SM, Johnson DE, Grandis JR

ErbB receptors in the biology and pathology of the aerodigestive tract.

Experimental cell research

Morgan S, Grandis JR

Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells.

Journal of cellular biochemistry

Lin HY, Sun M, Tang HY, Simone TM, Wu YH, Grandis JR, Cao HJ, Davis PJ, Davis FB

Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Koppikar P, Choi SH, Egloff AM, Cai Q, Suzuki S, Freilino M, Nozawa H, Thomas SM, Gooding WE, Siegfried JM, Grandis JR

Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion.

Clinical cancer research : an official journal of the American Association for Cancer Research

Nozawa H, Howell G, Suzuki S, Zhang Q, Qi Y, Klein-Seetharaman J, Wells A, Grandis JR, Thomas SM

Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth.

Molecular cancer therapeutics

Yan Z, Zou H, Tian F, Grandis JR, Mixson AJ, Lu PY, Li LY

Introduction: head and neck cancer.

Seminars in oncology

Vokes EE, Cohen EE, Grandis JR

Emerging perspectives in epidermal growth factor receptor targeting in head and neck cancer.

Head & neck

Kim S, Grandis JR, Rinaldo A, Takes RP, Ferlito A

Long-term results of a phase III randomized trial of postoperative radiotherapy with or without carboplatin in patients with high-risk head and neck cancer.

The Laryngoscope

Argiris A, Karamouzis MV, Johnson JT, Heron DE, Myers E, Eibling D, Cano E, Urba S, Gluckman J, Grandis JR, Wang Y, Agarwala SS

Immunohistochemical analysis of phosphotyrosine signal transducer and activator of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in head and neck cancers and metastatic lymph nodes.

Clinical cancer research : an official journal of the American Association for Cancer Research

Seethala RR, Gooding WE, Handler PN, Collins B, Zhang Q, Siegfried JM, Grandis JR

Gefitinib potentiates myeloid cell differentiation by ATRA.

Leukemia

Miranda MB, Duan R, Thomas SM, Grandis JR, Redner RL, Jones JE, Johnson DE

Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer.

Frontiers in bioscience : a journal and virtual library

Bhola NE, Grandis JR

Clinical applications of gene therapy in head and neck cancer.

Current gene therapy

Karamouzis MV, Argiris A, Grandis JR

STAT-mediated EGFR signaling in cancer.

Journal of cellular biochemistry

Quesnelle KM, Boehm AL, Grandis JR

NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Ferris RL, Grandis JR

Multiple cytokine and growth factor serum biomarkers predict therapeutic response and survival in advanced-stage head and neck cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research

Bigbee WL, Grandis JR, Siegfried JM

Aberrant kinase signaling: lessons from head and neck cancer.

Future oncology (London, England)

Nelson EG, Grandis JR

Association of the EGFR intron 1 CA repeat length with lung cancer risk.

Molecular carcinogenesis

Zhang W, Weissfeld JL, Romkes M, Land SR, Grandis JR, Siegfried JM

Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.

Molecular cancer therapeutics

Zhang Q, Bhola NE, Lui VW, Siwak DR, Thomas SM, Gubish CT, Siegfried JM, Mills GB, Shin D, Grandis JR

Altered inflammatory gene expression underlies increased susceptibility to murine postoperative ileus with advancing age.

American journal of physiology. Gastrointestinal and liver physiology

Moore BA, Albers KM, Davis BM, Grandis JR, Tögel S, Bauer AJ

Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Fridman JS, Caulder E, Hansbury M, Liu X, Yang G, Wang Q, Lo Y, Zhou BB, Pan M, Thomas SM, Grandis JR, Zhuo J, Yao W, Newton RC, Friedman SM, Scherle PA, Vaddi K

Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: the role of STAT1.

Molecular pharmacology

Lui VW, Boehm AL, Koppikar P, Leeman RJ, Johnson D, Ogagan M, Childs E, Freilino M, Grandis JR

Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib.

Experimental cell research

Liu X, Carlisle DL, Swick MC, Gaither-Davis A, Grandis JR, Siegfried JM

Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.

Head & neck

Lin CJ, Grandis JR, Carey TE, Gollin SM, Whiteside TL, Koch WM, Ferris RL, Lai SY

The role of CD44 in HNSCC.

Cancer biology & therapy

Nelson AD, Grandis JR

Established and emerging concepts in epidermal growth factor receptor biology.

International journal of radiation oncology, biology, physics

Grandis JR

Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma.

Cancer research

Thomas SM, Bhola NE, Zhang Q, Contrucci SC, Wentzel AL, Freilino ML, Gooding WE, Siegfried JM, Chan DC, Grandis JR

Understanding the presence and function of erythropoietin receptors on cancer cells.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Lai SY, Grandis JR

Frameless stereotactic radiosurgery for recurrent head and neck carcinoma.

Technology in cancer research & treatment

Voynov G, Heron DE, Burton S, Grandis J, Quinn A, Ferris R, Ozhasoglu C, Vogel W, Johnson J

Research education and training in otolaryngology: meeting summary and research opportunities.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Grandis JR, Battey JF, Califf RM, Chole RA, Gantz BJ, Gates GA, Gorelic L, Hannley MT, Hardwick KS, Harris JP, Kapoor WN, Lai SY, Lalwani AK, Minor LB, Nadol JP, Post JC, Roland PS, Schechter AM, Schuller DE, Sklare DA, Wackym PA, Weber RS, Weymuller EA, Wolf GT, Woodson GE

Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting.

Clinical cancer research : an official journal of the American Association for Cancer Research

Sok JC, Coppelli FM, Thomas SM, Lango MN, Xi S, Hunt JL, Freilino ML, Graner MW, Wikstrand CJ, Bigner DD, Gooding WE, Furnari FB, Grandis JR

Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Zhang W, Stabile LP, Keohavong P, Romkes M, Grandis JR, Traynor AM, Siegfried JM

Importance of molecular analysis in detecting cervical lymph node metastasis in head and neck squamous cell carcinoma.

Head & neck

Elsheikh MN, Rinaldo A, Hamakawa H, Mahfouz ME, Rodrigo JP, Brennan J, Devaney KO, Grandis JR, Ferlito A

Prognostic biomarkers in head and neck cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Grandis JR

Epidermal growth factor receptor biology in head and neck cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Kalyankrishna S, Grandis JR

Head and neck cancer: recent advances and new standards of care.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Forastiere AA, Trotti A, Pfister DG, Grandis JR

Women in otolaryngology: closing the gender gap.

Current opinion in otolaryngology & head and neck surgery

Ferguson BJ, Grandis JR

Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.

Proceedings of the National Academy of Sciences of the United States of America

Zhang Q, Thomas SM, Lui VW, Xi S, Siegfried JM, Fan H, Smithgall TE, Mills GB, Grandis JR

STAT3 as a therapeutic target in head and neck cancer.

Expert opinion on biological therapy

Leeman RJ, Lui VW, Grandis JR

Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesis.

Journal of the National Cancer Institute

Xi S, Dyer KF, Kimak M, Zhang Q, Gooding WE, Chaillet JR, Chai RL, Ferrell RE, Zamboni B, Hunt J, Grandis JR

Advances in molecular diagnostics and therapeutics in head and neck cancer.

Current treatment options in oncology

Chai RL, Grandis JR

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.

Biochemical pharmacology

Dent P, Han SI, Mitchell C, Studer E, Yacoub A, Grandis J, Grant S, Krystal GW, Hylemon PB

Role of NQO1 polymorphisms as risk factors for squamous cell carcinoma of the head and neck.

Oral oncology

Begleiter A, Norman A, Leitao D, Cabral T, Hewitt D, Pan S, Grandis JR, Siegfried JM, El-Sayed S, Sutherland D, Ross DA, Kerr PD

Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma.

Oncogene

Lai SY, Childs EE, Xi S, Coppelli FM, Gooding WE, Wells A, Ferris RL, Grandis JR

Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells.

Neoplasia (New York, N.Y.)

Thomas SM, Grandis JR, Wentzel AL, Gooding WE, Lui VW, Siegfried JM

Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract.

Molecular carcinogenesis

Buch S, Zhu B, Davis AG, Odom D, Siegfried JM, Grandis JR, Romkes M

Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients.

The Laryngoscope

Hathaway B, Landsittel DP, Gooding W, Whiteside TL, Grandis JR, Siegfried JM, Bigbee WL, Ferris RL

IL-12 receptor-mediated upregulation of FasL in human ovarian carcinoma cells.

International journal of cancer. Journal international du cancer

Gorelik E, Edwards RP, Feng X, Marrangoni AM, Grandis JR, Drenning SD, Velikokhatnaya L, Kwon JA, Lokshin AE

Head and neck cancer: meeting summary and research opportunities.

Cancer research

Grandis JR, Pietenpol JA, Greenberger JS, Pelroy RA, Mohla S

Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38.

Clinical cancer research : an official journal of the American Association for Cancer Research

Thomas SM, Zeng Q, Epperly MW, Gooding WE, Pastan I, Wang QC, Greenberger J, Grandis JR

Mutation of p53 in head and neck squamous cell carcinoma correlates with Bcl-2 expression and increased susceptibility to cisplatin-induced apoptosis.

Head & neck

Andrews GA, Xi S, Pomerantz RG, Lin CJ, Gooding WE, Wentzel AL, Wu L, Sidransky D, Grandis JR

SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.

Cancer research

Zhang Q, Thomas SM, Xi S, Smithgall TE, Siegfried JM, Kamens J, Gooding WE, Grandis JR

Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research

Chen Z, Zhang X, Li M, Wang Z, Wieand HS, Grandis JR, Shin DM

The gender gap in a surgical subspecialty: analysis of career and lifestyle factors.

Archives of otolaryngology--head & neck surgery

Grandis JR, Gooding WE, Zamboni BA, Wagener MM, Drenning SD, Miller L, Doyle KJ, Mackinnon SE, Wagner RL

Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility.

Gastroenterology

Schwarz NT, Kalff JC, Türler A, Speidel N, Grandis JR, Billiar TR, Bauer AJ

Constitutive activation of Stat5b contributes to carcinogenesis in vivo.

Cancer research

Xi S, Zhang Q, Gooding WE, Smithgall TE, Grandis JR

Antitumor effects of epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research

Niwa H, Wentzel AL, Li M, Gooding WE, Lui VW, Grandis JR

Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon.

American journal of physiology. Gastrointestinal and liver physiology

Moore BA, Türler A, Pezzone MA, Dyer K, Grandis J, Bauer AJ

Responsiveness to the retinoic acid receptor-selective retinoid LGD1550 correlates with abrogation of transforming growth factor alpha/epidermal growth factor receptor autocrine signaling in head and neck squamous carcinoma cells.

Clinical cancer research : an official journal of the American Association for Cancer Research

Lango M, Wentzel AL, Song JI, Xi S, Johnson DE, Lamph WW, Miller L, Grandis JR

Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma.

Cancer research

Thomas SM, Coppelli FM, Wells A, Gooding WE, Song J, Kassis J, Drenning SD, Grandis JR

Tissue distribution of liposome-mediated epidermal growth factor receptor antisense gene therapy.

Cancer gene therapy

Thomas SM, Zeng Q, Dyer KF, Suscovich TJ, Kanter PM, Whalen JD, Watkins SF, Grandis JR

Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2.

Oncogene

Steinman RA, Wentzel A, Lu Y, Stehle C, Grandis JR

Targeting epidermal growth factor receptor: novel therapeutics in the management of cancer.

Expert review of anticancer therapy

Khalil MY, Grandis JR, Shin DM

Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck.

The Journal of biological chemistry

Xi S, Zhang Q, Dyer KF, Lerner EC, Smithgall TE, Gooding WE, Kamens J, Grandis JR

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth.

Proceedings of the National Academy of Sciences of the United States of America

Leong PL, Andrews GA, Johnson DE, Dyer KF, Xi S, Mai JC, Robbins PD, Gadiparthi S, Burke NA, Watkins SF, Grandis JR

Gene therapy for the treatment of oral squamous cell carcinoma.

Journal of dental research

Xi S, Grandis JR

Phospholipase C-gamma1 in tumor progression.

Clinical & experimental metastasis

Wells A, Grandis JR

Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Li M, Ye C, Feng C, Riedel F, Liu X, Zeng Q, Grandis JR

Lipopolysaccharide preconditioning and cross-tolerance: the induction of protective mechanisms for rat intestinal ileus.

Gastroenterology

Schwarz NT, Engel B, Eskandari MK, Kalff JC, Grandis JR, Bauer AJ

STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research

Kijima T, Niwa H, Steinman RA, Drenning SD, Gooding WE, Wentzel AL, Xi S, Grandis JR

EGFR antisense treatment of human HNSCC cell lines down-regulates VEGF expression and endothelial cell migration.

International journal of oncology

Riedel F, Götte K, Li M, Hörmann K, Grandis JR

Stat3 activation in prostatic carcinomas.

The Prostate

Dhir R, Ni Z, Lou W, DeMiguel F, Grandis JR, Gao AC

Lack of toxicity of EGFR antisense gene therapy.

Journal of experimental therapeutics & oncology

Zeng Q, Kanter PM, Dhir R, Gooding WE, Huang L, Grandis JR

Differential function of STAT5 isoforms in head and neck cancer growth control.

Oncogene

Leong PL, Xi S, Drenning SD, Dyer KF, Wentzel AL, Lerner EC, Smithgall TE, Grandis JR

Selective activation of members of the signal transducers and activators of transcription family in prostate carcinoma.

The Journal of urology

Ni Z, Lou W, Lee SO, Dhir R, DeMiguel F, Grandis JR, Gao AC

Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck.

Journal of the National Cancer Institute

Lango MN, Dyer KF, Lui VW, Gooding WE, Gubish C, Siegfried JM, Grandis JR

EGFR-mediated cell cycle regulation.

Anticancer research

Lui VW, Grandis JR

Expression of androgen receptor, epidermal growth factor receptor, and transforming growth factor alpha in salivary duct carcinoma.

Archives of otolaryngology--head & neck surgery

Fan CY, Melhem MF, Hosal AS, Grandis JR, Barnes EL

The role of topical antibiotic prophylaxis in patients undergoing contaminated head and neck surgery with flap reconstruction.

The Laryngoscope

Simons JP, Johnson JT, Yu VL, Vickers RM, Gooding WE, Myers EN, Pou AM, Wagner RL, Grandis JR

Human leukocyte antigen class I allelic and haplotype loss in squamous cell carcinoma of the head and neck: clinical and immunogenetic consequences.

Clinical cancer research : an official journal of the American Association for Cancer Research

Grandis JR, Falkner DM, Melhem MF, Gooding WE, Drenning SD, Morel PA

Determination of intermediate biomarker expression levels by quantitative reverse transcription-polymerase chain reaction in oral mucosa of cancer patients treated with liarozole.

Clinical cancer research : an official journal of the American Association for Cancer Research

Zeng Q, Smith DC, Suscovich TJ, Gooding WE, Trump DL, Grandis JR

STAT signaling in head and neck cancer.

Oncogene

Song JI, Grandis JR

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Grandis JR, Drenning SD, Zeng Q, Watkins SC, Melhem MF, Endo S, Johnson DE, Huang L, He Y, Kim JD

Endoscopic sphenopalatine artery ligation is an effective method of treatment for posterior epistaxis.

American journal of rhinology

Snyderman CH, Goldman SA, Carrau RL, Ferguson BJ, Grandis JR

Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium.

Clinical cancer research : an official journal of the American Association for Cancer Research

Drenning SD, Marcovitch AJ, Johnson DE, Melhem MF, Tweardy DJ, Grandis JR

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

The Journal of clinical investigation

Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, Tweardy DJ

Growth and differentiation of rat hepatocytes: changes in transcription factors HNF-3, HNF-4, STAT-3, and STAT-5.

Biochemical and biophysical research communications

Runge D, Runge DM, Drenning SD, Bowen WC, Grandis JR, Michalopoulos GK

Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter.

Journal of the National Cancer Institute

He Y, Zeng Q, Drenning SD, Melhem MF, Tweardy DJ, Huang L, Grandis JR

Subglottic injury, gastric juice, corticosteroids, and peptide growth factors in a porcine model.

The Laryngoscope

Yellon RF, Szeremeta W, Grandis JR, Diguisseppe P, Dickman PS

Tumor Board Conference from the University of Pittsburgh.

Oncology (Williston Park, N.Y.)

Pitman KT, Agarwala SS, Cano ER, Eibling DE, Fagan JJ, Grandis JR, Johnson JT, Myers EN, Russavage JM, Snyderman CH, Weismann JL

Lack of serologic evidence for Helicobacter pylori infection in head and neck cancer.

Head & neck

Grandis JR, Perez-Perez GI, Yu VL, Johnson JT, Blaser MJ

Role of subglottic injury, gastric juice, and peptide growth factors in a porcine model.

International anesthesiology clinics

Yellon RF, Szeremeta W, Grandis JR, Diguisseppe P, Dickman PS

Antitumor activity of interleukin-1 alpha and cisplatin in a murine model system.

Archives of otolaryngology--head & neck surgery

Grandis JR, Chang MJ, Yu WD, Johnson CS

The efficacy of topical antibiotic prophylaxis for contaminated head and neck surgery.

The Laryngoscope

Grandis JR, Vickers RM, Rihs JD, Yu VL, Wagner RL, Kachman KK, Johnson JT

Simultaneous presentation of malignant external otitis and temporal bone cancer.

Archives of otolaryngology--head & neck surgery

Grandis JR, Hirsch BE, Yu VL

Treatment of idiopathic sudden sensorineural hearing loss.

The American journal of otology

Grandis JR, Hirsch BE, Wagener MM

Head and neck cancer.

Archives of otolaryngology--head & neck surgery

Snyderman CH, Grandis JR, Johnson JT

TGF-alpha and EGFR in head and neck cancer.

Journal of cellular biochemistry. Supplement

Grandis JR, Tweardy DJ

Synergistic enhancement by interleukin-1 alpha of cisplatin-mediated antitumor activity in RIF-1 tumor-bearing C3H/HeJ mice.

Cancer chemotherapy and pharmacology

Johnson CS, Chang MJ, Yu WD, Modzelewski RA, Grandis JR, Vlock DR, Furmanski P

Postoperative wound infection. A poor prognostic sign for patients with head and neck cancer.

Cancer

Grandis JR, Snyderman CH, Johnson JT, Yu VL, D'Amico F

The role of peptide growth factors in head and neck carcinoma.

Otolaryngologic clinics of North America

Grandis JR, Tweardy DJ

The efficacy of perioperative antibiotic therapy on recovery following tonsillectomy in adults: randomized double-blind placebo-controlled trial.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Grandis JR, Johnson JT, Vickers RM, Yu VL, Wagener MM, Wagner RL, Kachman KA

Stomal recurrence after laryngectomy: interrelated risk factor study.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Rubin J, Johnson JT, Myers EN

Extramedullary plasmacytoma of the thyroid associated with a serum monoclonal gammopathy.

Archives of otolaryngology--head & neck surgery

Rubin J, Johnson JT, Killeen R, Barnes L

Aural irrigation with water: a potential pathogenic mechanism for inducing malignant external otitis?

The Annals of otology, rhinology, and laryngology

Rubin J, Yu VL, Kamerer DB, Wagener M

Malignant external otitis: utility of CT in diagnosis and follow-up.

Radiology

Rubin J, Curtin HD, Yu VL, Kamerer DB

Efficacy of oral ciprofloxacin plus rifampin for treatment of malignant external otitis.

Archives of otolaryngology--head & neck surgery

Rubin J, Stoehr G, Yu VL, Muder RR, Matador A, Kamerer DB

Malignant external otitis in children.

The Journal of pediatrics

Rubin J, Yu VL, Stool SE

Bacteriologic analysis of wound infection following major head and neck surgery.

Archives of otolaryngology--head & neck surgery

Rubin J, Johnson JT, Wagner RL, Yu VL